Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And

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Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments - Molecular Basis Of Amyloid-beta Protein Aggregation And Fibril Formation
Molecular Basis of Amyloid-Beta Protein Aggregation and Fibril Formation
By: Philippe Derreumaux
Publisher:
ICP
Print ISBN: 9781848167544, 1848167547
eText ISBN: 9781908979650, 1908979658
Pages: 464
Format: EPUB
Available from $ 66.00 USD
SKU 9781908979650
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39–43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.
A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.
This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.
Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease.
Contents:
Cellular and In Vitro Aspects of Amyloid-Beta (Aβ) Aggregation:
Amyloid Hypothesis: Molecular and Cellular Aspects of Toxicity (Rakez Kayed and Cristian A Lasagna-Reeves)
Models of Wild-Type and Disease-Causing Mutant β-Amyloid Fibrils. Insights from Solid-State Nuclear Magnetic Resonance Spectroscopy (Stephen C Meredith)
Biophysical Characterization of Aβ Assembly (Eric Y Hayden and David B Teplow)
Coordination of Metal Ions to β-Amyloid Peptide: Impact on Alzheimer's Disease (Peter Faller, Giovanni La Penna, Christelle Hureau and Sara Furlan)
Amyloidogenesis, Neurogenesis, Learning, and Memory in Alzheimer's Disease: Lessons from Transgenic Mouse Models (Laure Verret and Claire Rampon)