Click Here to Download: https://ouo.io/FN1Ugep Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases By: James Devillers Publisher: CRC Press Print ISBN: 9781498741804, 1498741800 eText ISBN: 9781351647694, 1351647695 Edition: 1st Copyright year: 2018 Format: EPUB Available from $ 23.18 USD SKU 9781351647694R90 There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.
