Click Here to Download: https://ouo.io/rwvRhyx Dose Finding by the Continual Reassessment Method By: Ying Kuen Cheung Publisher: Chapman and Hall/CRC Print ISBN: 9781420091519, 1420091514 eText ISBN: 9781420091526, 1420091522 Edition: 1st Copyright year: 2011 Format: PDF Available from $ 23.18 USD SKU 9781420091526R90 As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to novel methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the Continual Reassessment Method features: Real clinical trial examples that illustrate the methods and techniques throughout the book Detailed calibration techniques that enable biostatisticians to design a CRM in timely manner Limitations of the CRM are outlined to aid in correct use of method This book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package âdfcrmâ for the CRM and its major variants. The author recognizes cliniciansâ skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in Dose Finding by the Continual Reassessment Method will lessen the statisticianâs burden and encourage the continuing development and implementation of model-based dose-finding methods. Additional ISBNs 9781322612782, 1322612781
