Click Here to Download: https://ouo.io/zgy59L Evolution-adjusted Tumor Pathophysiology: The Novel Language of Tumor Biology By: Albrecht Reichle Publisher: Springer Print ISBN: 9789400768659, 9400768656 eText ISBN: 9789400768666, 9400768664 Copyright year: 2013 Format: PDF Available from $ 189.00 USD SKU 9789400768666 Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.
