Click Here to Download: https://ouo.io/1yTgYC Heart Rate and Rhythm Molecular Basis, Pharmacological Modulation and Clinical Implications By: Onkar N. Tripathi Publisher: Springer Print ISBN: 9783642175749, 3642175740 eText ISBN: 9783642175756, 3642175759 Copyright year: 2011 Format: PDF Available from $ 269.00 USD SKU 9783642175756 Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2 handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
