Click Here to Download: https://ouo.io/4Tl1sw Iron Acquisition by the Genus Mycobacterium History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development By: B. Rowe Byers Publisher: Springer Print ISBN: 9783319003023, 331900302X eText ISBN: 9783319003030, 3319003038 Copyright year: 2013 Format: EPUB Available from $ 69.99 USD SKU 9783319003030 Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
