Click Here to Download: https://ouo.io/s5rqz8 Mathematical Modeling and Validation in Physiology Applications to the Cardiovascular and Respiratory Systems By: Jerry J. Batzel Publisher: Springer Print ISBN: 9783642328817, 3642328814 eText ISBN: 9783642328824, 3642328822 Copyright year: 2013 Format: EPUB Available from $ 84.99 USD SKU 9783642328824 This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.
