Click Here to Download: https://ouo.io/hRaYzu Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) By: Caroline Fonta Publisher: Springer Print ISBN: 9789401771962, 9401771960 eText ISBN: 9789401771979, 9401771979 Copyright year: 2015 Format: PDF Available from $ 269.00 USD SKU 9789401771979 Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.
