Oral Bioavailability Assessment: Basics And Strategies For Drug Discovery And Development

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Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
By: Ayman F. El-Kattan; Mike S. Lee
Publisher:
Wiley-Blackwell
Print ISBN: 9781118916698, 1118916697
eText ISBN: 9781118916933, 111891693X
Edition: 1st
Copyright year: 2017
Format: EPUB
Available from $ 140.99 USD
SKU 9781118916933
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.

• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development