Click Here to Download: https://ouo.io/eZ2ZA9p Target Validation in Drug Discovery By: Metcalf, Brian W.; Dillon, Susan Publisher: Academic Press Print ISBN: 9780123693938, 0123693934 eText ISBN: 9780123693938, 9780080465975, 0080465978 Pages: 296 Format: PDF Available from $ 110.00 USD SKU 9780123693938 This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as second generation drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
