Click Here to Download: https://ouo.io/vJTump Thymic Development and Selection of T Lymphocytes By: Thomas Boehm Publisher: Springer Print ISBN: 9783642402517, 3642402518 eText ISBN: 9783642402524, 3642402526 Copyright year: 2014 Format: EPUB Available from $ 139.00 USD SKU 9783642402524 The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
