Click Here to Download: https://ouo.io/0Q2Awm1 Tumor Metabolome Targeting and Drug Development By: Steven Kanner Publisher: Humana Press Print ISBN: 9781461495444, 146149544X eText ISBN: 9781461495451, 1461495458 Copyright year: 2014 Format: EPUB Available from $ 149.00 USD SKU 9781461495451 In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
